Structural insights and cytotoxicity evaluation of benz[e]indole pyrazolyl-substituted amides

• Main Authors: Abdul Qaiyum, Ramle, Nadia Nabihah, Mohd Yusof Chan, Ng, Min Phin, Tan, Chun Hoe, Sim, Kae Shin, Tiekink, Edward R. T. *, Fei, Chee Chin
• Format: Article
• Published: Springer 2023
• Subjects: QD Chemistry; QP Physiology; RC Internal medicine
• Online Access: http://eprints.sunway.edu.my/2869/; https://link.springer.com/article/10.1007/s11030-023-10662-2
• Institution: Sunway University

Five new compounds of benz[e]indole pyrazolyl-substituted amides (2a–e) were synthesised in low to good yields via the direct amide-coupling reaction between a pyrazolyl derivative containing a carboxylic acid and several amine substrates. The molecular structures were determined by various spectros...