Analysis of genetic variants in myeloproliferative neoplasms using a 22-gene next-generation sequencing panel

• Main Authors: Tan, Jaymi *, Chow, Yock Ping, Norzila, Zainul Abidin, Chang, Kian Meng, Veena, Selvaratnam, Nor Rafeah, Tumian, Poh, Yang Ming, Abhi, Veerakumarasivam *, Laffan, Michael Arthur, Wong, Chieh Lee
• Format: Article
• Language: English
• Published: BMC 2022
• Subjects: QH Natural history; RC Internal medicine
• Online Access: http://eprints.sunway.edu.my/2949/1/Abhi%20Veerakumarasivam_Analysis%20of%20genetic%20variants%20in%20myeloproliferative%20neoplasms.pdf; http://eprints.sunway.edu.my/2949/; https://bmcmedgenomics.biomedcentral.com/articles/10.1186/s12920-021-01145-0
• Institution: Sunway University

Background: The Philadelphia (Ph)-negative myeloproliferative neoplasms (MPNs), namely essential thrombocythaemia (ET), polycythaemia vera (PV) and primary myelofibrosis (PMF), are a group of chronic clonal haematopoietic disorders that have the propensity to advance into bone marrow failure or acut...