Methylation-based markers of aging and lifestyle-related factors and risk of breast cancer: a pooled analysis of four prospective studies

• Main Authors: Dugue, Pierre-Antioine, Bodelon, Clara, Chung, Felicia Fei Lei *, Brewer, Hannah R, Ambatipudi, Srikant, Sampson, Joshua N, Cuenin, Cyrille, Chajes, Veronique, Romieu, Isabelle, Fiorito, Giovanni, Sacerdote, Carlotta, Krogh, Vittorio, Panico, Salvatore, Tumino, Rosaria, Vineis, Paolo, Polidoro, Silvia, Baglietto, Laura, English, Dallas, Severi, Gianluca, Giles, Graham G, Milne, Roger L, Herceg, Zdenko, Garcia-Closas, Montserrat, Flanagan, James M, Southey, Melissa C
• Format: Article
• Published: BMC 2022
• Subjects: QH Natural history; QP Physiology; RC Internal medicine
• Online Access: http://eprints.sunway.edu.my/3059/; https://doi.org/10.1186/s13058-022-01554-8
• Institution: Sunway University

Background: DNA methylation in blood may reflect adverse exposures accumulated over the lifetime and could therefore provide potential improvements in the prediction of cancer risk. A substantial body of research has shown associations between epigenetic aging and risk of disease, including cancer....