Effects of partially dismantling the CD4 binding site glycan fence of HIV-1 envelope glycoprotein trimers on neutralizing antibody induction

• Main Authors: Crooks, Ema T, Osawa, Keiko, Tong, Tommy Yuh Koon *, Grimley, Samantha L, Dai, Yang D, Whalen, Robert G, Kulp, Daniel W, Menis, Sergey, Schief, William R, Binley, James M
• Format: Article
• Language: English
• Published: Elsevier 2017
• Subjects: Q Science (General); QR355 Virology
• Online Access: http://eprints.sunway.edu.my/479/1/Tommy%20Tong.pdf; http://eprints.sunway.edu.my/479/; http://dx.doi.org/10.1016/j.virol.2017.02.024
• Institution: Sunway University

Previously, VLPs bearing JR-FL strain HIV-1 Envelope trimers elicited potent neutralizing antibodies (nAbs) in 2/8 rabbits PLoS Pathog 11(5): e1004932) by taking advantage of a naturally absent glycan at position 197 that borders the CD4 binding site (CD4bs). In new immunizations, we attempted to im...