Apoptosis in Acanthamoeba castellanii belonging to the T4 genotype

Here we describe features of apoptosis in unicellular Acanthamoeba castellanii belonging to the T4 genotype. When exposed to apoptosis-inducing compounds such as doxorubicin, A. castellanii trophozoites exhibited cell shrinkage and membrane blebbing as observed microscopically, DNA fragmentation usi...

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Main Authors:	Baig, Abdul Mannan, Lalani, S., Khan, Naveed Ahmed
Format:	Article
Published:	Wiley-VCH Verlag 2017
Subjects:	Q Science (General) QR Microbiology
Online Access:	http://eprints.sunway.edu.my/494/
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Institution:	Sunway University

id	my.sunway.eprints.494
record_format	eprints
spelling	my.sunway.eprints.4942020-10-01T09:29:49Z http://eprints.sunway.edu.my/494/ Apoptosis in Acanthamoeba castellanii belonging to the T4 genotype Baig, Abdul Mannan Lalani, S.* Khan, Naveed Ahmed * Q Science (General) QR Microbiology Here we describe features of apoptosis in unicellular Acanthamoeba castellanii belonging to the T4 genotype. When exposed to apoptosis-inducing compounds such as doxorubicin, A. castellanii trophozoites exhibited cell shrinkage and membrane blebbing as observed microscopically, DNA fragmentation using agarose gel electrophoresis, and phosphatidylserine (PS) externalization using annexinVimmunostaining. Overall,thesefindingssuggesttheexistenceofapoptosis inA.castellaniipossiblymediatedbyintrinsicapoptoticcascade.Furtherresearchin this field could provide avenues to selectively induce apoptosis in A. castellanii by triggering intrinsic apoptotic cascade. Wiley-VCH Verlag 2017 Article PeerReviewed Baig, Abdul Mannan and Lalani, S.* and Khan, Naveed Ahmed * (2017) Apoptosis in Acanthamoeba castellanii belonging to the T4 genotype. Journal of Basic Microbiology, 9999. pp. 1-6. ISSN 0233 111X
institution	Sunway University
building	Sunway Campus Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Sunway University
content_source	Sunway Institutional Repository
url_provider	http://eprints.sunway.edu.my/
topic	Q Science (General) QR Microbiology
spellingShingle	Q Science (General) QR Microbiology Baig, Abdul Mannan Lalani, S.* Khan, Naveed Ahmed * Apoptosis in Acanthamoeba castellanii belonging to the T4 genotype
description	Here we describe features of apoptosis in unicellular Acanthamoeba castellanii belonging to the T4 genotype. When exposed to apoptosis-inducing compounds such as doxorubicin, A. castellanii trophozoites exhibited cell shrinkage and membrane blebbing as observed microscopically, DNA fragmentation using agarose gel electrophoresis, and phosphatidylserine (PS) externalization using annexinVimmunostaining. Overall,thesefindingssuggesttheexistenceofapoptosis inA.castellaniipossiblymediatedbyintrinsicapoptoticcascade.Furtherresearchin this field could provide avenues to selectively induce apoptosis in A. castellanii by triggering intrinsic apoptotic cascade.
format	Article
author	Baig, Abdul Mannan Lalani, S.* Khan, Naveed Ahmed *
author_facet	Baig, Abdul Mannan Lalani, S.* Khan, Naveed Ahmed *
author_sort	Baig, Abdul Mannan
title	Apoptosis in Acanthamoeba castellanii belonging to the T4 genotype
title_short	Apoptosis in Acanthamoeba castellanii belonging to the T4 genotype
title_full	Apoptosis in Acanthamoeba castellanii belonging to the T4 genotype
title_fullStr	Apoptosis in Acanthamoeba castellanii belonging to the T4 genotype
title_full_unstemmed	Apoptosis in Acanthamoeba castellanii belonging to the T4 genotype
title_sort	apoptosis in acanthamoeba castellanii belonging to the t4 genotype
publisher	Wiley-VCH Verlag
publishDate	2017
url	http://eprints.sunway.edu.my/494/
_version_	1680323379583778816

Apoptosis in Acanthamoeba castellanii belonging to the T4 genotype

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