One-pot, microwave-assisted synthesis of polymethylene-bridged bis(1H-1,2,4triazol-5(3)-amines) and their tautomerism
A highly selective and efficient method for the synthesis of 3,3’(5,5’)-polymethylene-bis(1H1,2,4-triazol-5(3)-amines) was developed using the reaction of dicarboxylic acids and aminoguanidine in an aqueous medium. This one-pot, microwave-promoted method was proved to be scalable affording the des...
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my.sunway.eprints.9092020-10-07T09:21:39Z http://eprints.sunway.edu.my/909/ One-pot, microwave-assisted synthesis of polymethylene-bridged bis(1H-1,2,4triazol-5(3)-amines) and their tautomerism Phei, Felicia Lin Lim Lee, Ming Hu Tiekink, Edward R. T. * Dolzhenko, Anton V QD Chemistry A highly selective and efficient method for the synthesis of 3,3’(5,5’)-polymethylene-bis(1H1,2,4-triazol-5(3)-amines) was developed using the reaction of dicarboxylic acids and aminoguanidine in an aqueous medium. This one-pot, microwave-promoted method was proved to be scalable affording the desired products in good yields and purity. The scope of the method was successfully explored by the preparation of a small library of polymethylene-bis(1H-1,2,4-triazol-5(3)-amines) with different alkyl chain linkers. The annular prototropic tautomerism in the prepared compounds was studied using NMR spectroscopy and X-ray crystallography. Elsevier 2018 Article PeerReviewed text en cc_by_nc_nd_4 http://eprints.sunway.edu.my/909/1/Tiekink%20One%20pot%20microwave.pdf Phei, Felicia Lin Lim and Lee, Ming Hu and Tiekink, Edward R. T. * and Dolzhenko, Anton V (2018) One-pot, microwave-assisted synthesis of polymethylene-bridged bis(1H-1,2,4triazol-5(3)-amines) and their tautomerism. Tetrahedron Letters, 59 (42). pp. 3792-3796. ISSN 0040-4039 http://www.elsevier.com |
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QD Chemistry Phei, Felicia Lin Lim Lee, Ming Hu Tiekink, Edward R. T. * Dolzhenko, Anton V One-pot, microwave-assisted synthesis of polymethylene-bridged bis(1H-1,2,4triazol-5(3)-amines) and their tautomerism |
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A highly selective and efficient method for the synthesis of 3,3’(5,5’)-polymethylene-bis(1H1,2,4-triazol-5(3)-amines)
was developed using the reaction of dicarboxylic acids and
aminoguanidine in an aqueous medium. This one-pot, microwave-promoted method was proved to be scalable affording the desired products in good yields and purity. The scope of the method was successfully explored by the preparation of a small library of polymethylene-bis(1H-1,2,4-triazol-5(3)-amines) with different alkyl chain linkers. The annular prototropic tautomerism in the prepared compounds was studied using NMR spectroscopy and X-ray crystallography. |
format |
Article |
author |
Phei, Felicia Lin Lim Lee, Ming Hu Tiekink, Edward R. T. * Dolzhenko, Anton V |
author_facet |
Phei, Felicia Lin Lim Lee, Ming Hu Tiekink, Edward R. T. * Dolzhenko, Anton V |
author_sort |
Phei, Felicia Lin Lim |
title |
One-pot, microwave-assisted synthesis of polymethylene-bridged bis(1H-1,2,4triazol-5(3)-amines) and their tautomerism |
title_short |
One-pot, microwave-assisted synthesis of polymethylene-bridged bis(1H-1,2,4triazol-5(3)-amines) and their tautomerism |
title_full |
One-pot, microwave-assisted synthesis of polymethylene-bridged bis(1H-1,2,4triazol-5(3)-amines) and their tautomerism |
title_fullStr |
One-pot, microwave-assisted synthesis of polymethylene-bridged bis(1H-1,2,4triazol-5(3)-amines) and their tautomerism |
title_full_unstemmed |
One-pot, microwave-assisted synthesis of polymethylene-bridged bis(1H-1,2,4triazol-5(3)-amines) and their tautomerism |
title_sort |
one-pot, microwave-assisted synthesis of polymethylene-bridged bis(1h-1,2,4triazol-5(3)-amines) and their tautomerism |
publisher |
Elsevier |
publishDate |
2018 |
url |
http://eprints.sunway.edu.my/909/1/Tiekink%20One%20pot%20microwave.pdf http://eprints.sunway.edu.my/909/ http://www.elsevier.com |
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1680323400658059264 |