Cloning of the human thiopurine methyltransferase (TMPT) gene fragment for generation of copy numbers in absolute real time PCR / Ahmad Firdaus Mohd Azhar

• Main Author: Mohd Azhar, Ahmad Firdaus
• Format: Thesis
• Language: English
• Published: 2008
• Subjects: Pharmaceutical ethics; Pharmaceutical chemistry
• Online Access: https://ir.uitm.edu.my/id/eprint/101896/1/101896.PDF; https://ir.uitm.edu.my/id/eprint/101896/
• Institution: Universiti Teknologi Mara

Thiopurine Methyltransferase (TPMT) is an enzyme involved in the metabolism of thiopurine drugs. The enzyme has been found to be polymorphic resulting in wide phannacokinetic and pharmacodynamic differences among patients. Outcome of therapy has been correlated with the expression of protein in diff...