Colon-specific delivery of 5-fluorouracil from zinc pectinate spheroids through in situ intra-capsular ethylcellulose-pectin plug formation / Assad Ali Faraj Elyagoby

• Main Author: Elyagoby, Assad Ali Faraj
• Format: Thesis
• Language: English
• Published: 2014
• Subjects: Diseases of the digestive system. Gastroenterology
• Online Access: http://ir.uitm.edu.my/id/eprint/27748/1/TP_ASSAD%20ALI%20FARAJ%20ELYAGOBY%20PH%2014_5.pdf; http://ir.uitm.edu.my/id/eprint/27748/
• Institution: Universiti Teknologi Mara

Conventional fluid-bed and immersion film coating of hydrophilic zinc pectinate spheroids using ethylcellulose-pectin mixture is met with fast drug release due to hydrophobic ethylcellulose coat detachment. This study explored in situ intra-capsular spheroid coating for colon-specific delivery of 5-...