Use of a Tendon/Ligament Cell Sheet with Mesenchymal Stem Cells and Cyclic Stretch Stimulus for Tendon / Ligament Tissue Restoration / Yasuyuki Morita...[et al.]
It can be relatively difficult for damaged tendon or ligament tissue to heal perfectly due to the inability to self-cure. Therefore, tendon and ligament tissue engineering has been used as a restorative method. Perfect tissue restoration, however, has yet to be achieved. In other research, cell shee...
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Faculty of Mechanical Engineering Universiti Teknologi MARA (UiTM)
2018
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my.uitm.ir.394102020-12-22T03:18:02Z http://ir.uitm.edu.my/id/eprint/39410/ Use of a Tendon/Ligament Cell Sheet with Mesenchymal Stem Cells and Cyclic Stretch Stimulus for Tendon / Ligament Tissue Restoration / Yasuyuki Morita...[et al.] Yasuyuki, Morita Fuga, Matsubara Matsubara, Toku Yang, Ju TJ Mechanical engineering and machinery Mechanical movements It can be relatively difficult for damaged tendon or ligament tissue to heal perfectly due to the inability to self-cure. Therefore, tendon and ligament tissue engineering has been used as a restorative method. Perfect tissue restoration, however, has yet to be achieved. In other research, cell sheets have been applied to various different types of tissues and organs for regeneration. In this study, we attempted to fabricate a tendon/ligament cell sheet for use in tissue engineering. Firstly, human bone marrow mesenchymal stem cells (hBMSCs), which have excellent proliferative abilities, were harvested and formed into a cell sheet. Then, a cyclic stretching stimulus was applied to the hBMSC sheet to enhance cell differentiation into tendon/ligament cells. The results showed that the work was successful in promoting differentiation, resulting in a tendon/ligament cell sheet. These results suggest that this method is effective for tendon/ligament tissue engineering. Faculty of Mechanical Engineering Universiti Teknologi MARA (UiTM) 2018 Article PeerReviewed text en http://ir.uitm.edu.my/id/eprint/39410/1/39410.pdf Yasuyuki, Morita and Fuga, Matsubara and Matsubara, Toku and Yang, Ju (2018) Use of a Tendon/Ligament Cell Sheet with Mesenchymal Stem Cells and Cyclic Stretch Stimulus for Tendon / Ligament Tissue Restoration / Yasuyuki Morita...[et al.]. Journal of Mechanical Engineering (JMechE), SI 5 (3). pp. 1-11. ISSN 18235514 |
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TJ Mechanical engineering and machinery Mechanical movements Yasuyuki, Morita Fuga, Matsubara Matsubara, Toku Yang, Ju Use of a Tendon/Ligament Cell Sheet with Mesenchymal Stem Cells and Cyclic Stretch Stimulus for Tendon / Ligament Tissue Restoration / Yasuyuki Morita...[et al.] |
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It can be relatively difficult for damaged tendon or ligament tissue to heal perfectly due to the inability to self-cure. Therefore, tendon and ligament tissue engineering has been used as a restorative method. Perfect tissue restoration, however, has yet to be achieved. In other research, cell sheets have been applied to various different types of tissues and organs for regeneration. In this study, we attempted to fabricate a tendon/ligament cell sheet for use in tissue engineering. Firstly, human bone marrow mesenchymal stem cells (hBMSCs), which have excellent proliferative abilities, were harvested and formed into a cell sheet. Then, a cyclic stretching stimulus was applied to the hBMSC sheet to enhance cell differentiation into tendon/ligament cells. The results showed that the work was successful in promoting differentiation, resulting in a tendon/ligament cell sheet. These results suggest that this method is effective for tendon/ligament tissue engineering. |
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Article |
author |
Yasuyuki, Morita Fuga, Matsubara Matsubara, Toku Yang, Ju |
author_facet |
Yasuyuki, Morita Fuga, Matsubara Matsubara, Toku Yang, Ju |
author_sort |
Yasuyuki, Morita |
title |
Use of a Tendon/Ligament Cell Sheet with Mesenchymal Stem Cells and Cyclic Stretch Stimulus for Tendon / Ligament Tissue Restoration / Yasuyuki Morita...[et al.] |
title_short |
Use of a Tendon/Ligament Cell Sheet with Mesenchymal Stem Cells and Cyclic Stretch Stimulus for Tendon / Ligament Tissue Restoration / Yasuyuki Morita...[et al.] |
title_full |
Use of a Tendon/Ligament Cell Sheet with Mesenchymal Stem Cells and Cyclic Stretch Stimulus for Tendon / Ligament Tissue Restoration / Yasuyuki Morita...[et al.] |
title_fullStr |
Use of a Tendon/Ligament Cell Sheet with Mesenchymal Stem Cells and Cyclic Stretch Stimulus for Tendon / Ligament Tissue Restoration / Yasuyuki Morita...[et al.] |
title_full_unstemmed |
Use of a Tendon/Ligament Cell Sheet with Mesenchymal Stem Cells and Cyclic Stretch Stimulus for Tendon / Ligament Tissue Restoration / Yasuyuki Morita...[et al.] |
title_sort |
use of a tendon/ligament cell sheet with mesenchymal stem cells and cyclic stretch stimulus for tendon / ligament tissue restoration / yasuyuki morita...[et al.] |
publisher |
Faculty of Mechanical Engineering Universiti Teknologi MARA (UiTM) |
publishDate |
2018 |
url |
http://ir.uitm.edu.my/id/eprint/39410/1/39410.pdf http://ir.uitm.edu.my/id/eprint/39410/ |
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