Human Cytomegalovirus: A culprit of infection in renal and bone marrow transplant recipients in Malaysia / Mohd Fahmi Mastuki ... [et al.]
Human cytomegalovirus (HCMV) infection may cause substantial morbidity and mortality after renal and bone marrow transplantation. The aims of this study were to determine the incidence of HCMV infection in renal and bone marrow transplant recipients and to investigate its associations with HCMV dise...
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my.uitm.ir.546772021-12-22T04:19:45Z https://ir.uitm.edu.my/id/eprint/54677/ Human Cytomegalovirus: A culprit of infection in renal and bone marrow transplant recipients in Malaysia / Mohd Fahmi Mastuki ... [et al.] Mastuki, Mohd Fahmi Sinniah, Mangalam Mohamed Shakrin, Nik Noorul Shakira Masri, Siti Norbaya Mohd Taib, Niazlin Infectious and parasitic diseases Diseases of the genitourinary system. Urology Human cytomegalovirus (HCMV) infection may cause substantial morbidity and mortality after renal and bone marrow transplantation. The aims of this study were to determine the incidence of HCMV infection in renal and bone marrow transplant recipients and to investigate its associations with HCMV disease, gender and races. This analysis involved 200 blood samples from renal and bone marrow transplant recipients from January 2011 to June 2012. The overall incidence of HCMV infection in the study group was 70.5% (141/200) where renal and bone marrow transplants account for 78.0% (78/100) and 63.0% (63/100), respectively. The incidence of HCMV infection in renal transplantation differed significantly by sex (p<0.05) where it was higher in males (78.2%) than in females (21.8%) but there was no statistically significant difference by sex in bone marrow transplantation in which males and females account for 47.6% and 52.4% respectively. The incidence of HCMV infection was not significantly different (p>0.05) by races in both transplantation types. The percentages are as follows: 45% (Malay), 24% (Chinese), 17% (Indian) and 15% (other indigenous races) in renal transplantation while 75% (Malay), 3% (Chinese), 8% (Indian) and 13% (other indigenous races) in bone marrow transplantation. The most seen symptoms were fever followed by generalised lethargy and headache. This study has shown that HCMV viral load has no significant association between age, gender, races and HCMV disease. Treatment with anti-HCMV therapy results in decline in HCMV load, usually to undetectable. Faculty of Health Sciences, Universiti Teknologi MARA 2019-06 Article PeerReviewed text en https://ir.uitm.edu.my/id/eprint/54677/1/54677.pdf ID54677 Mastuki, Mohd Fahmi and Sinniah, Mangalam and Mohamed Shakrin, Nik Noorul Shakira and Masri, Siti Norbaya and Mohd Taib, Niazlin (2019) Human Cytomegalovirus: A culprit of infection in renal and bone marrow transplant recipients in Malaysia / Mohd Fahmi Mastuki ... [et al.]. Health Scope, 1. pp. 65-70. ISSN 2735-0649 http://healthscopefsk.com/ |
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Infectious and parasitic diseases Diseases of the genitourinary system. Urology Mastuki, Mohd Fahmi Sinniah, Mangalam Mohamed Shakrin, Nik Noorul Shakira Masri, Siti Norbaya Mohd Taib, Niazlin Human Cytomegalovirus: A culprit of infection in renal and bone marrow transplant recipients in Malaysia / Mohd Fahmi Mastuki ... [et al.] |
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Human cytomegalovirus (HCMV) infection may cause substantial morbidity and mortality after renal and bone marrow transplantation. The aims of this study were to determine the incidence of HCMV infection in renal and bone marrow transplant recipients and to investigate its associations with HCMV disease, gender and races. This analysis involved 200 blood samples from renal and bone marrow transplant recipients from January 2011 to June 2012. The overall incidence of HCMV infection in the study group was 70.5% (141/200) where renal and bone marrow transplants account for 78.0% (78/100) and 63.0% (63/100), respectively. The incidence of HCMV infection in renal transplantation differed significantly by sex (p<0.05) where it was higher in males (78.2%) than in females (21.8%) but there was no statistically significant difference by sex in bone marrow transplantation in which males and females account for 47.6% and 52.4% respectively. The incidence of HCMV infection was not significantly different (p>0.05) by races in both transplantation types. The percentages are as follows: 45% (Malay), 24% (Chinese), 17% (Indian) and 15% (other indigenous races) in renal transplantation while 75% (Malay), 3% (Chinese), 8% (Indian) and 13% (other indigenous races) in bone marrow transplantation. The most seen symptoms were fever followed by generalised lethargy and headache. This study has shown that HCMV viral load has no significant association between age, gender, races and HCMV disease. Treatment with anti-HCMV therapy results in decline in HCMV load, usually to undetectable. |
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Article |
author |
Mastuki, Mohd Fahmi Sinniah, Mangalam Mohamed Shakrin, Nik Noorul Shakira Masri, Siti Norbaya Mohd Taib, Niazlin |
author_facet |
Mastuki, Mohd Fahmi Sinniah, Mangalam Mohamed Shakrin, Nik Noorul Shakira Masri, Siti Norbaya Mohd Taib, Niazlin |
author_sort |
Mastuki, Mohd Fahmi |
title |
Human Cytomegalovirus: A culprit of infection in renal and bone marrow transplant recipients in Malaysia / Mohd Fahmi Mastuki ... [et al.] |
title_short |
Human Cytomegalovirus: A culprit of infection in renal and bone marrow transplant recipients in Malaysia / Mohd Fahmi Mastuki ... [et al.] |
title_full |
Human Cytomegalovirus: A culprit of infection in renal and bone marrow transplant recipients in Malaysia / Mohd Fahmi Mastuki ... [et al.] |
title_fullStr |
Human Cytomegalovirus: A culprit of infection in renal and bone marrow transplant recipients in Malaysia / Mohd Fahmi Mastuki ... [et al.] |
title_full_unstemmed |
Human Cytomegalovirus: A culprit of infection in renal and bone marrow transplant recipients in Malaysia / Mohd Fahmi Mastuki ... [et al.] |
title_sort |
human cytomegalovirus: a culprit of infection in renal and bone marrow transplant recipients in malaysia / mohd fahmi mastuki ... [et al.] |
publisher |
Faculty of Health Sciences, Universiti Teknologi MARA |
publishDate |
2019 |
url |
https://ir.uitm.edu.my/id/eprint/54677/1/54677.pdf https://ir.uitm.edu.my/id/eprint/54677/ http://healthscopefsk.com/ |
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1720439848429420544 |