Structural studies of transient receptor potential channels (TRPs) using molecular modeling and dynamic simulation / Wan Dalila Wan Chik

Transient Receptor Potential Canonical (TRPC) channel was the first group of TRP homologs that was cloned in mammals. The channel consists of seven subfamily members in this family. TRPC4 channels are nonselective cation channels permeable to Ca2+ that are expressed in various organs and cell types...

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Main Author: Wan Chik, Wan Dalila
Format: Thesis
Language:English
Published: 2019
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Online Access:https://ir.uitm.edu.my/id/eprint/82984/1/82984.pdf
https://ir.uitm.edu.my/id/eprint/82984/
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Institution: Universiti Teknologi Mara
Language: English
id my.uitm.ir.82984
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spelling my.uitm.ir.829842024-03-04T01:46:09Z https://ir.uitm.edu.my/id/eprint/82984/ Structural studies of transient receptor potential channels (TRPs) using molecular modeling and dynamic simulation / Wan Dalila Wan Chik Wan Chik, Wan Dalila RS Pharmacy and materia medica Transient Receptor Potential Canonical (TRPC) channel was the first group of TRP homologs that was cloned in mammals. The channel consists of seven subfamily members in this family. TRPC4 channels are nonselective cation channels permeable to Ca2+ that are expressed in various organs and cell types including numerous types of neurons, cardiovascular system, skeletal muscle cells, kidney, and immune cells. TRPC4 channels assemble into a tetrameric structure in the plasma membrane. The S4- S5 linker of TRPC4 has been shown to regulate the open-close of the channel by interacting with the S6 helix. Previous homology models that were built based on the potassium channel structure predicted inter-domain interactions were formed by G503 and the S623 between the linker with the S6 helix. Mutagenesis experiments of TRPC4 and TRPC5 supported that the mutation of the conserved glycine impaired the interaction, which resulted to the channel opening, and causing cell death due to the influx of Ca2+. 2019 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/82984/1/82984.pdf Structural studies of transient receptor potential channels (TRPs) using molecular modeling and dynamic simulation / Wan Dalila Wan Chik. (2019) PhD thesis, thesis, Universiti Teknologi MARA (UiTM). <http://terminalib.uitm.edu.my/82984.pdf>
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic RS Pharmacy and materia medica
spellingShingle RS Pharmacy and materia medica
Wan Chik, Wan Dalila
Structural studies of transient receptor potential channels (TRPs) using molecular modeling and dynamic simulation / Wan Dalila Wan Chik
description Transient Receptor Potential Canonical (TRPC) channel was the first group of TRP homologs that was cloned in mammals. The channel consists of seven subfamily members in this family. TRPC4 channels are nonselective cation channels permeable to Ca2+ that are expressed in various organs and cell types including numerous types of neurons, cardiovascular system, skeletal muscle cells, kidney, and immune cells. TRPC4 channels assemble into a tetrameric structure in the plasma membrane. The S4- S5 linker of TRPC4 has been shown to regulate the open-close of the channel by interacting with the S6 helix. Previous homology models that were built based on the potassium channel structure predicted inter-domain interactions were formed by G503 and the S623 between the linker with the S6 helix. Mutagenesis experiments of TRPC4 and TRPC5 supported that the mutation of the conserved glycine impaired the interaction, which resulted to the channel opening, and causing cell death due to the influx of Ca2+.
format Thesis
author Wan Chik, Wan Dalila
author_facet Wan Chik, Wan Dalila
author_sort Wan Chik, Wan Dalila
title Structural studies of transient receptor potential channels (TRPs) using molecular modeling and dynamic simulation / Wan Dalila Wan Chik
title_short Structural studies of transient receptor potential channels (TRPs) using molecular modeling and dynamic simulation / Wan Dalila Wan Chik
title_full Structural studies of transient receptor potential channels (TRPs) using molecular modeling and dynamic simulation / Wan Dalila Wan Chik
title_fullStr Structural studies of transient receptor potential channels (TRPs) using molecular modeling and dynamic simulation / Wan Dalila Wan Chik
title_full_unstemmed Structural studies of transient receptor potential channels (TRPs) using molecular modeling and dynamic simulation / Wan Dalila Wan Chik
title_sort structural studies of transient receptor potential channels (trps) using molecular modeling and dynamic simulation / wan dalila wan chik
publishDate 2019
url https://ir.uitm.edu.my/id/eprint/82984/1/82984.pdf
https://ir.uitm.edu.my/id/eprint/82984/
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