Synthesis and antimicrobial activities of some new 6-iodoquinazoline-based Schiff bases / Ahmed M Alafeefy ... [et al.]

A library of thirteen new quinazoline-based Schiff bases was synthesized by simple, straightforward documented chemical procedures. Their skeletal structure was confirmed by IR, NMR, MS, and elemental analyses. The final compounds were also screened for their activities against eight selected microb...

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Main Authors: M Alafeefy, Ahmed, Ashraf, Kamran, E Zain, Mohamed, Sultan, Sadia
Format: Article
Language:English
Published: Faculty of Pharmacy 2024
Subjects:
Online Access:https://ir.uitm.edu.my/id/eprint/94562/1/94562.pdf
https://ir.uitm.edu.my/id/eprint/94562/
http://ijpncs.uitm.edu.my/index.php/en/ijpncs-journal
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Institution: Universiti Teknologi Mara
Language: English
id my.uitm.ir.94562
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spelling my.uitm.ir.945622024-05-30T14:54:23Z https://ir.uitm.edu.my/id/eprint/94562/ Synthesis and antimicrobial activities of some new 6-iodoquinazoline-based Schiff bases / Ahmed M Alafeefy ... [et al.] ijpnacs M Alafeefy, Ahmed Ashraf, Kamran E Zain, Mohamed Sultan, Sadia Antibacterial agents A library of thirteen new quinazoline-based Schiff bases was synthesized by simple, straightforward documented chemical procedures. Their skeletal structure was confirmed by IR, NMR, MS, and elemental analyses. The final compounds were also screened for their activities against eight selected microbial strains (two gram-positive and two gram-negative bacteria in addition to four fungal strains). Nine out of the thirteen tested compounds showed remarkable antimicrobial activities. However, six compounds, namely 7, 10, 13, 15, 16 and 18, showed antibacterial and antifungal activities, while compounds 9, 14 and 17 were devoid of antifungal and showed only antibacterial activities. The best activity was obtained by compounds 10 and 15, which were against Bacillus subtilis. The best MIC (1.90 µg/ml) and (3.9 µg/ml) were obtained by compound 10 against Bacillus subtilis and Staphylococcus aureus, respectively. Aspergillus fumigatus and Syncephalastrum racemosum were the most sensitive filamentous fungi, where compound 10 inhibited their growth at MIC (15.63 and 62.50 µg/ml), respectively. Faculty of Pharmacy 2024 Article PeerReviewed text en https://ir.uitm.edu.my/id/eprint/94562/1/94562.pdf Synthesis and antimicrobial activities of some new 6-iodoquinazoline-based Schiff bases / Ahmed M Alafeefy ... [et al.]. (2024) International Journal of Pharmaceutical, Nutraceutical and Cosmetic Science (IJPNaCS) <https://ir.uitm.edu.my/view/publication/International_Journal_of_Pharmaceutical,_Nutraceutical_and_Cosmetic_Science_=28IJPNaCS=29/>, 7 (1). pp. 12-23. ISSN 2682-8146 http://ijpncs.uitm.edu.my/index.php/en/ijpncs-journal
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Antibacterial agents
spellingShingle Antibacterial agents
M Alafeefy, Ahmed
Ashraf, Kamran
E Zain, Mohamed
Sultan, Sadia
Synthesis and antimicrobial activities of some new 6-iodoquinazoline-based Schiff bases / Ahmed M Alafeefy ... [et al.]
description A library of thirteen new quinazoline-based Schiff bases was synthesized by simple, straightforward documented chemical procedures. Their skeletal structure was confirmed by IR, NMR, MS, and elemental analyses. The final compounds were also screened for their activities against eight selected microbial strains (two gram-positive and two gram-negative bacteria in addition to four fungal strains). Nine out of the thirteen tested compounds showed remarkable antimicrobial activities. However, six compounds, namely 7, 10, 13, 15, 16 and 18, showed antibacterial and antifungal activities, while compounds 9, 14 and 17 were devoid of antifungal and showed only antibacterial activities. The best activity was obtained by compounds 10 and 15, which were against Bacillus subtilis. The best MIC (1.90 µg/ml) and (3.9 µg/ml) were obtained by compound 10 against Bacillus subtilis and Staphylococcus aureus, respectively. Aspergillus fumigatus and Syncephalastrum racemosum were the most sensitive filamentous fungi, where compound 10 inhibited their growth at MIC (15.63 and 62.50 µg/ml), respectively.
format Article
author M Alafeefy, Ahmed
Ashraf, Kamran
E Zain, Mohamed
Sultan, Sadia
author_facet M Alafeefy, Ahmed
Ashraf, Kamran
E Zain, Mohamed
Sultan, Sadia
author_sort M Alafeefy, Ahmed
title Synthesis and antimicrobial activities of some new 6-iodoquinazoline-based Schiff bases / Ahmed M Alafeefy ... [et al.]
title_short Synthesis and antimicrobial activities of some new 6-iodoquinazoline-based Schiff bases / Ahmed M Alafeefy ... [et al.]
title_full Synthesis and antimicrobial activities of some new 6-iodoquinazoline-based Schiff bases / Ahmed M Alafeefy ... [et al.]
title_fullStr Synthesis and antimicrobial activities of some new 6-iodoquinazoline-based Schiff bases / Ahmed M Alafeefy ... [et al.]
title_full_unstemmed Synthesis and antimicrobial activities of some new 6-iodoquinazoline-based Schiff bases / Ahmed M Alafeefy ... [et al.]
title_sort synthesis and antimicrobial activities of some new 6-iodoquinazoline-based schiff bases / ahmed m alafeefy ... [et al.]
publisher Faculty of Pharmacy
publishDate 2024
url https://ir.uitm.edu.my/id/eprint/94562/1/94562.pdf
https://ir.uitm.edu.my/id/eprint/94562/
http://ijpncs.uitm.edu.my/index.php/en/ijpncs-journal
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