Triterpenes and steroids from the leaves of Aglaia exima (Meliaceae)

Triterpenes and steroids from the leaves of Aglaia exima (Meliaceae)

A study on the leaves of Aglaia exima led to the isolation of one new and seven known compounds: six triterpenoids and two steroids. Their structures were elucidated and analyzed mainly by using spectroscopic methods; 1D and 2D NMR, mass spectrometry, UV spectrometry and X-ray. All the triterpenoids...

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Bibliographic Details
Main Author: Leong, K.H.
Format: Article
Language:English
Published: Elsevier 2012
Subjects:
Q Science (General)
QD Chemistry
QH301 Biology
QK Botany
R Medicine
RC0254 Neoplasms. Tumors. Oncology (including Cancer)
RM Therapeutics. Pharmacology
RS Pharmacy and materia medica
RV Botanic, Thomsonian, and eclectic medicine
Online Access:http://eprints.um.edu.my/10001/1/1Triterpenes_and_steroids_from_the_leaves_of_Aglaia_exima_%28Meliaceae%29.pdf
http://eprints.um.edu.my/10001/
http://www.sciencedirect.com/science/article/pii/S0367326X12002808
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Institution: Universiti Malaya
Language: English
Description
Summary:A study on the leaves of Aglaia exima led to the isolation of one new and seven known compounds: six triterpenoids and two steroids. Their structures were elucidated and analyzed mainly by using spectroscopic methods; 1D and 2D NMR, mass spectrometry, UV spectrometry and X-ray. All the triterpenoids and steroids were measured in vitro for their cytotoxic activities against eight cancer cell lines; lung (A549), prostate (DU-145), skin (SK-MEL-5), pancreatic (BxPC-3), liver (Hep G2), colon (HT-29), breast (MCF-7) and (MDA-MB-231). The new cycloartane triterpenoid, 24(E)-cycloart-24-ene-26-ol-3-one 1, showed potent cytotoxic activity against colon (HT-29) cancer cell line (IC50 11.5 μM).

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