Ceftriaxone resistance and genes encoding extended-spectrum ß-lactamase among non-typhoidal salmonella species from a tertiary care hospital in Kuala Lumpur, Malaysia

• Main Authors: Karunakaran, R., Sun, T.T., Rahim, F.F., Bee, B.L., Sam, I.C., Kahar-Bador, M., Hassan, H., Puthucheary, S.D.
• Format: Article
• Language: English
• Published: 2012
• Subjects: R Medicine (General)
• Online Access: http://eprints.um.edu.my/10170/1/Ceftriaxone_Resistance_and_Genes_Encoding_Extended-Spectrum.pdf; http://eprints.um.edu.my/10170/
• Institution: Universiti Malaya

The prevalence of ceftriaxone resistance and the associated genes encoding extended-spectrum ß-lactamase (ESBL) was determined in 149 non-duplicate non-typhoidal Salmonella isolated in 2008–2009 from patients in a tertiary care hospital in Kuala Lumpur, Malaysia. The resistance rate to ceftriaxone was 2.7z (2/74) in 2008, 4.0z (3/75) in 2009, and 3.4z (5/149) overall. CTX-M ESBL genes were detected in 2 of the 5 ceftriaxone-resistant isolates. The prevalence of ceftriaxone resistance, although low, is a concern because it limits therapeutic options. Continued surveillance of ceftriaxone resistance is important to monitor its trends