Effects of ambient glycaemic state on growth hormone responsiveness in insulin-dependent diabetes
We wished to examine the effects of ambient glycaemia on hypothalamic somatostatinergic tone in insulin-dependent diabetes mellitus. After 6-hour periods of either euglycaemia (5 mmol/l) or hyperglycaemia (15 mmol/l), exercise-induced GH secretion was measured. Seven insulin dependent diabetics with...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1991
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| Subjects: | |
| Online Access: | http://eprints.um.edu.my/10470/1/Effects_of_ambient_glycaemic_state_on_growth_hormone.pdf http://eprints.um.edu.my/10470/ |
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| Institution: | Universiti Malaya |
| Language: | English |
| Summary: | We wished to examine the effects of ambient glycaemia on hypothalamic somatostatinergic tone in insulin-dependent diabetes mellitus. After 6-hour periods of either euglycaemia (5 mmol/l) or hyperglycaemia (15 mmol/l), exercise-induced GH secretion was measured. Seven insulin dependent diabetics with no evidence of complications were recruited. There was no significant difference between
basal GH levels during euglycaemia and hyperglycaemia
(5.50 vs 5.53 mU/l). Nor was there a significant difference
when mean \ GH levels (33.9 vs 27.4 mU/l) or mean area
under GH curve (2331 vs 4038 mU min/l) during euglycaemia
or hyperglycaemia were compared. We find no evidence therefore to support short-term effects of ambient glucose concentration on GH responsiveness, and by inference no direct effect of shortterm changes in glycaemic control on hypothalamic release of somatostatin in the aetiology of GH hypersecretion in insulin-dependent diabetes mellitus. |
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