Addisonian-like crisis in congenital hypopituitarism and cholestatic jaundice
A six-week-old male infant was admitted for investigation of cholestasis and pale stools. He became lethargic and apnoeic with prolonged seizures after a percutaneous liver biopsy. Subsequent investigations showed conjugated hyperbilirubinaemia, elevated liver enzymes, and hypoglycaemia. The radinuc...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Malaysian Medical Association
2003
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| Subjects: | |
| Online Access: | http://eprints.um.edu.my/10921/1/Addisonian-like_crisis_in_congenital_hypopituitarism.pdf http://eprints.um.edu.my/10921/ http://www.e-mjm.org/2003/v58n2/Congenital_Hypopituitarism.pdf |
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| Institution: | Universiti Malaya |
| Language: | English |
| Summary: | A six-week-old male infant was admitted for investigation of cholestasis and pale stools. He became lethargic and apnoeic with prolonged seizures after a percutaneous liver biopsy. Subsequent investigations showed conjugated hyperbilirubinaemia, elevated liver enzymes, and hypoglycaemia. The radinuclide hepatobiliary scintigraphy was non-excretory. After an operative cholangiogram, the infant developed Addisonian-like crisis with bradycardia, hypotension, respiratory distress, metabolic acidosis, hypoglycaemia, hyponatraemia, and hyperkalaemia. Blood investigations confirmed congenital hypopituitarism. Hormone replacement therapy with L-thyroxine and cortisone acetate resulted in dissolution of jaundice and the reduction of the liver size. |
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