Formation of Nonionic Branched-Chain Glycolipids Nano-Emulsion for drug delivery systems
The effect of incorporating new nonionic glyco lipid surfactants on the properties of a model water/nonionic surfactant/oil nano-emulsion system was investigated using branched-chain alkyl glycosides : 2-hexyldecyl-p(la)-D -glucoside (2-HDG) and 2-hexyldecyl-p(la)-D -maltoside (2-HDM), whose structu...
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my.um.eprints.110932019-05-31T04:44:55Z http://eprints.um.edu.my/11093/ Formation of Nonionic Branched-Chain Glycolipids Nano-Emulsion for drug delivery systems Ahmad, Noraini Ramsch, Roland Llinas, Meritxell Solans, Conxita Hashim, Rauzah Tajuddin, Hairul Anuar QD Chemistry The effect of incorporating new nonionic glyco lipid surfactants on the properties of a model water/nonionic surfactant/oil nano-emulsion system was investigated using branched-chain alkyl glycosides : 2-hexyldecyl-p(la)-D -glucoside (2-HDG) and 2-hexyldecyl-p(la)-D -maltoside (2-HDM), whose structures are closely related to glycero-glycolipids. Both 2-HDG and 2-HDM have an identical hydrophobic chain (C 16), but the former consists a monosaccharide glucose head group, in contrast to the latter which has a disaccharide maltose unit. Consequently, their hydrophilic-lipophilic balance (HLB) is different. The results obtained have shown that these branched-ehain alkyl glycosides affect differently the stability of the nano-emu lsions. Compared to the model nanoemulsion, the presence of 2-HDG reduces the oil droplet size, whereas 2-HDM modify the properties of the model nano-emulsion system in terms of its droplet size and storage time stability at high temperature. These nano-emulsions have been proven capable of encapsulating ketoprofen, showing a fast release of almost 100% in 24 hours . Thus, both branched-chain alkyl glycosides are suitable as nano-cmulsion stabilizing agents and as drug delivery systems in the future . 2014-08 Conference or Workshop Item PeerReviewed text en http://eprints.um.edu.my/11093/1/Formation_of_Nonionic_Branched-Chain.pdf Ahmad, Noraini and Ramsch, Roland and Llinas, Meritxell and Solans, Conxita and Hashim, Rauzah and Tajuddin, Hairul Anuar (2014) Formation of Nonionic Branched-Chain Glycolipids Nano-Emulsion for drug delivery systems. In: Seoul International Conference on Applied Science and Engineering (SICASE), 29-31 Aug 2014, Seoul, South Korea. (Submitted) |
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QD Chemistry Ahmad, Noraini Ramsch, Roland Llinas, Meritxell Solans, Conxita Hashim, Rauzah Tajuddin, Hairul Anuar Formation of Nonionic Branched-Chain Glycolipids Nano-Emulsion for drug delivery systems |
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The effect of incorporating new nonionic glyco lipid surfactants on the properties of a model water/nonionic surfactant/oil nano-emulsion system was investigated using branched-chain alkyl glycosides : 2-hexyldecyl-p(la)-D -glucoside (2-HDG) and 2-hexyldecyl-p(la)-D -maltoside (2-HDM), whose structures are closely related to glycero-glycolipids. Both 2-HDG and 2-HDM have an identical hydrophobic chain (C 16), but the former consists a monosaccharide glucose head group, in contrast to the latter which has a disaccharide maltose unit. Consequently, their hydrophilic-lipophilic balance (HLB) is different. The results obtained have shown that these branched-ehain alkyl
glycosides affect differently the stability of the nano-emu lsions. Compared to the model nanoemulsion, the presence of 2-HDG reduces the oil droplet size, whereas 2-HDM modify the properties of the model nano-emulsion system in terms of its droplet size and storage time stability at high temperature. These nano-emulsions have been proven capable of encapsulating ketoprofen, showing a fast release of almost 100% in 24 hours . Thus, both branched-chain alkyl glycosides are suitable as nano-cmulsion stabilizing agents and as drug delivery systems in the future . |
format |
Conference or Workshop Item |
author |
Ahmad, Noraini Ramsch, Roland Llinas, Meritxell Solans, Conxita Hashim, Rauzah Tajuddin, Hairul Anuar |
author_facet |
Ahmad, Noraini Ramsch, Roland Llinas, Meritxell Solans, Conxita Hashim, Rauzah Tajuddin, Hairul Anuar |
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Ahmad, Noraini |
title |
Formation of Nonionic Branched-Chain Glycolipids Nano-Emulsion for drug delivery systems |
title_short |
Formation of Nonionic Branched-Chain Glycolipids Nano-Emulsion for drug delivery systems |
title_full |
Formation of Nonionic Branched-Chain Glycolipids Nano-Emulsion for drug delivery systems |
title_fullStr |
Formation of Nonionic Branched-Chain Glycolipids Nano-Emulsion for drug delivery systems |
title_full_unstemmed |
Formation of Nonionic Branched-Chain Glycolipids Nano-Emulsion for drug delivery systems |
title_sort |
formation of nonionic branched-chain glycolipids nano-emulsion for drug delivery systems |
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2014 |
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http://eprints.um.edu.my/11093/1/Formation_of_Nonionic_Branched-Chain.pdf http://eprints.um.edu.my/11093/ |
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