Large BRCA1 and BRCA2 genomic rearrangements in Malaysian high risk breast-ovarian cancer families

• Main Authors: Kang, P., Mariapun, S., Phuah, S.Y., Lim, L.S., Liu, J., Yoon, Sook-Yee, Thong, M.K., Taib, N.A.M., Yip, C.H., Teo, Soo-Hwang
• Format: Article
• Published: Kluwer (now part of Springer) 2010
• Subjects: Q Science (General); R Medicine
• Online Access: http://eprints.um.edu.my/12057/
• Institution: Universiti Malaya

Early studies of genetic predisposition due to the BRCA1 and BRCA2 genes have focused largely on sequence alterations, but it has now emerged that 4-28% of inherited mutations in the BRCA genes may be due to large genomic rearrangements of these genes. However, to date, there have been relatively fe...