Oppositinines A and B: New vasorelaxant beta-carboline alkaloids from neisosperma oppositifolia
A phytochemical study on the bark of Neisosperma oppositifolia (Apocynaceae) yielded two new beta-carboline indole alkaloids, oppositinines A (1) and B (2), together with five known alkaloids, isoreserpiline, isocarapanaubine, vobasine, 10-methoxydihydrocorynantheol-N-oxide, and ochropposinine oxind...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Published: |
Pharmaceutical Soc Japan
2010
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| Subjects: | |
| Online Access: | http://eprints.um.edu.my/12608/ |
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| Institution: | Universiti Malaya |
| Summary: | A phytochemical study on the bark of Neisosperma oppositifolia (Apocynaceae) yielded two new beta-carboline indole alkaloids, oppositinines A (1) and B (2), together with five known alkaloids, isoreserpiline, isocarapanaubine, vobasine, 10-methoxydihydrocorynantheol-N-oxide, and ochropposinine oxindole. Structural elucidation of 1 and 2 was performed using 21) NMR methods. Oppositinines A (1) and B (2) showed potent vasorelaxant effects on the rat aorta. |
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