The Arf GAP SMAP2 is Necessary for Organized Vesicle Budding from the Trans-Golgi-network and Subsequent Acrosome Formation in Spermiogenesis

• Main Authors: Funaki, T., Kon, S., Tanabe, K., Natsume, W., Sato, S., Shimizu, T., Yoshida, N., Wong, W.F., Ogura, A., Ogawa, T., Inoue, K., Ogonuki, N., Miki, H., Mochida, K., Endoh, K., Yomogida, K., Fukumoto, M., Horai, R., Iwakura, Y., Ito, C., Toshimori, K., Watanabe, T., Satake, M.
• Format: Article
• Published: American Society for Cell Biology 2013
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/13039/; http://www.molbiolcell.org/content/24/17/2633.long; http://dx.doi.org/10.1091/mbc.E13-05-0234
• Institution: Universiti Malaya

The trans-Golgi-network (TGN) functions as a hub organelle in the exocytosis of clathrin-coated membrane vesicles, and SMAP2 is an Arf GTPase activating protein that binds to both clathrin and the clathrin assembly protein (CALM). In the present study, SMAP2 was detected on the TGN in the pachytene...