Lumutinines A-D, linearly fused macroline-macroline and macroline-sarpagine bisindoles from alstonia macrophylla

Lumutinines A-D, linearly fused macroline-macroline and macroline-sarpagine bisindoles from alstonia macrophylla

Four new linearly fused bisindole alkaloids, lumutinines A D (1-4), were isolated from the stem-bark extract of Alstonia macrophylla. Lumutinines A (1) and B (2) represent the first examples of linear, ring A/F-fused macroline-macroline-type bisindoles, while lumutinines C (3) and D (4) were constit...

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Main Authors: Lim, Siew-Huah, Tan, Shin-Jowl, Low, Yun-Yee, Kam, Toh-Seok
Format: Article
Published: 2010
Subjects:
Q Science (General)
Online Access:http://eprints.um.edu.my/14691/
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Institution: Universiti Malaya
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spelling my.um.eprints.146912015-11-09T01:31:08Z http://eprints.um.edu.my/14691/ Lumutinines A-D, linearly fused macroline-macroline and macroline-sarpagine bisindoles from alstonia macrophylla Lim, Siew-Huah Tan, Shin-Jowl Low, Yun-Yee Kam, Toh-Seok Q Science (General) Four new linearly fused bisindole alkaloids, lumutinines A D (1-4), were isolated from the stem-bark extract of Alstonia macrophylla. Lumutinines A (1) and B (2) represent the first examples of linear, ring A/F-fused macroline-macroline-type bisindoles, while lumutinines C (3) and D (4) were constituted from the union of macroline and sarpagine moieties. A reinvestigation of the stereochemical assignment of alstoumerine (8) by NMR and X-ray diffraction analyses indicated that the configuration at C-16 and C-19 required revision. 2010 Article PeerReviewed Lim, Siew-Huah and Tan, Shin-Jowl and Low, Yun-Yee and Kam, Toh-Seok (2010) Lumutinines A-D, linearly fused macroline-macroline and macroline-sarpagine bisindoles from alstonia macrophylla. Journal of Natural Products, 74 (12). pp. 2556-2562.
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic Q Science (General)
spellingShingle Q Science (General)
Lim, Siew-Huah
Tan, Shin-Jowl
Low, Yun-Yee
Kam, Toh-Seok
Lumutinines A-D, linearly fused macroline-macroline and macroline-sarpagine bisindoles from alstonia macrophylla
description Four new linearly fused bisindole alkaloids, lumutinines A D (1-4), were isolated from the stem-bark extract of Alstonia macrophylla. Lumutinines A (1) and B (2) represent the first examples of linear, ring A/F-fused macroline-macroline-type bisindoles, while lumutinines C (3) and D (4) were constituted from the union of macroline and sarpagine moieties. A reinvestigation of the stereochemical assignment of alstoumerine (8) by NMR and X-ray diffraction analyses indicated that the configuration at C-16 and C-19 required revision.
format Article
author Lim, Siew-Huah
Tan, Shin-Jowl
Low, Yun-Yee
Kam, Toh-Seok
author_facet Lim, Siew-Huah
Tan, Shin-Jowl
Low, Yun-Yee
Kam, Toh-Seok
author_sort Lim, Siew-Huah
title Lumutinines A-D, linearly fused macroline-macroline and macroline-sarpagine bisindoles from alstonia macrophylla
title_short Lumutinines A-D, linearly fused macroline-macroline and macroline-sarpagine bisindoles from alstonia macrophylla
title_full Lumutinines A-D, linearly fused macroline-macroline and macroline-sarpagine bisindoles from alstonia macrophylla
title_fullStr Lumutinines A-D, linearly fused macroline-macroline and macroline-sarpagine bisindoles from alstonia macrophylla
title_full_unstemmed Lumutinines A-D, linearly fused macroline-macroline and macroline-sarpagine bisindoles from alstonia macrophylla
title_sort lumutinines a-d, linearly fused macroline-macroline and macroline-sarpagine bisindoles from alstonia macrophylla
publishDate 2010
url http://eprints.um.edu.my/14691/
_version_ 1643689878134718464

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