Chemoprevention of colorectal cancer with nonsteroidal anti-inflammatory drugs.

Chemoprevention of colorectal cancer with nonsteroidal anti-inflammatory drugs.

Colorectal carcinoma is one of the commonest solid organ tumors in the world and its prevalence appears to be increasing in Asia. Recently, there has been much interest in various chemotherapeutic agents for the management of this condition, in particular nonsteroidal anti-inflammatory drugs (NSAIDs...

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Main Authors: Hilmi, I., Goh, K.L.
Format: Article
Published: 2006
Subjects:
R Medicine
Online Access:http://eprints.um.edu.my/1616/
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Institution: Universiti Malaya
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spelling my.um.eprints.16162014-10-21T04:48:08Z http://eprints.um.edu.my/1616/ Chemoprevention of colorectal cancer with nonsteroidal anti-inflammatory drugs. Hilmi, I. Goh, K.L. R Medicine Colorectal carcinoma is one of the commonest solid organ tumors in the world and its prevalence appears to be increasing in Asia. Recently, there has been much interest in various chemotherapeutic agents for the management of this condition, in particular nonsteroidal anti-inflammatory drugs (NSAIDs). There is a large amount of data that suggest traditional NSAIDs, as well as the new cyclooxygenase (COX)-2 selective inhibitors such as rofecoxib and celecoxib, have a role in the setting of primary and secondary prevention, and adjuvant therapy of both sporadic colorectal carcinoma and familial adenomatous polyposis. This review examines some of this data, as well as the potential problems and limitations of using these agents, particularly in light of the recent withdrawal of rofecoxib. 2006 Article PeerReviewed Hilmi, I. and Goh, K.L. (2006) Chemoprevention of colorectal cancer with nonsteroidal anti-inflammatory drugs. Chinese Journal of Digestive Diseases, 7 (1). pp. 1-6. ISSN 1443-9611
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
spellingShingle R Medicine
Hilmi, I.
Goh, K.L.
Chemoprevention of colorectal cancer with nonsteroidal anti-inflammatory drugs.
description Colorectal carcinoma is one of the commonest solid organ tumors in the world and its prevalence appears to be increasing in Asia. Recently, there has been much interest in various chemotherapeutic agents for the management of this condition, in particular nonsteroidal anti-inflammatory drugs (NSAIDs). There is a large amount of data that suggest traditional NSAIDs, as well as the new cyclooxygenase (COX)-2 selective inhibitors such as rofecoxib and celecoxib, have a role in the setting of primary and secondary prevention, and adjuvant therapy of both sporadic colorectal carcinoma and familial adenomatous polyposis. This review examines some of this data, as well as the potential problems and limitations of using these agents, particularly in light of the recent withdrawal of rofecoxib.
format Article
author Hilmi, I.
Goh, K.L.
author_facet Hilmi, I.
Goh, K.L.
author_sort Hilmi, I.
title Chemoprevention of colorectal cancer with nonsteroidal anti-inflammatory drugs.
title_short Chemoprevention of colorectal cancer with nonsteroidal anti-inflammatory drugs.
title_full Chemoprevention of colorectal cancer with nonsteroidal anti-inflammatory drugs.
title_fullStr Chemoprevention of colorectal cancer with nonsteroidal anti-inflammatory drugs.
title_full_unstemmed Chemoprevention of colorectal cancer with nonsteroidal anti-inflammatory drugs.
title_sort chemoprevention of colorectal cancer with nonsteroidal anti-inflammatory drugs.
publishDate 2006
url http://eprints.um.edu.my/1616/
_version_ 1643686747279720448

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