Forkhead Box Transcription Factor (FOXO3a) mediates the cytotoxic effect of vernodalin in vitro and inhibits the breast tumor growth in vivo

• Main Authors: Sadagopan, S.K.A., Mohebali, N., Looi, C.Y., Hasanpourghadi, M., Pandurangan, A.K., Arya, A., Karimian, H., Mustafa, Mohd Rais
• Format: Article
• Published: BioMed Central 2015
• Subjects: R Medicine; RC0254 Neoplasms. Tumors. Oncology (including Cancer)
• Online Access: http://eprints.um.edu.my/16226/; https://doi.org/10.1186/s13046-015-0266-y
• Institution: Universiti Malaya

Background: Natural compounds have been demonstrated to lower breast cancer risk and sensitize tumor cells to anticancer therapies. Recently, we demonstrated that vernodalin (the active constituent of the medicinal herb Centratherum anthelminticum seeds) induces apoptosis in breast cancer cell-lines...