Does advancing male age influence the expression levels and localisation patterns of phospholipase C zeta (PLCζ) in human sperm?

• Main Authors: Yeste, M., Jones, C., Amdani, S.N., Yelumalai, S., Mounce, G., Da Silva, S.J.M., Child, T., Coward, K.
• Format: Article
• Published: Nature Publishing Group 2016
• Subjects: R Medicine; RG Gynecology and obstetrics
• Online Access: http://eprints.um.edu.my/18783/; http://dx.doi.org/10.1038/srep27543
• Institution: Universiti Malaya

Socio-economic factors have led to an increasing trend for couples to delay parenthood. However, advancing age exerts detrimental effects upon gametes which can have serious consequences upon embryo viability. While such effects are well documented for the oocyte, relatively little is known with reg...