Silver nanoparticles reduce brain inflammation and related neurotoxicity through induction of H2S-synthesizing enzymes

• Main Authors: Gonzalez-Carter, D.A., Leo, B.F., Ruenraroengsak, P., Chen, S., Goode, A.E., Theodorou, I.G., Chung, K.F., Carzaniga, R., Shaffer, M.S.P., Dexter, D.T., Ryan, M.P., Porter, A.E.
• Format: Article
• Published: Nature Publishing Group 2017
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/19182/; http://dx.doi.org/10.1038/srep42871
• Institution: Universiti Malaya

Silver nanoparticles (AgNP) are known to penetrate into the brain and cause neuronal death. However, there is a paucity in studies examining the effect of AgNP on the resident immune cells of the brain, microglia. Given microglia are implicated in neurodegenerative disorders such as Parkinson's...