Exome Sequencing Identifies Potentially Druggable Mutations in Nasopharyngeal Carcinoma

• Main Authors: Chow, Y.P., Tan, L.P., Chai, S.J., Abdul Aziz, N., Choo, S.W., Lim, P.V.H., Pathmanathan, R., Kornain, N.K.M., Lum, C.L., Pua, K.C., Yap, Y.Y., Tan, T.Y., Teo, S.H., Khoo, A.S.B., Patel, V.
• Format: Article
• Published: Nature Publishing Group 2017
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/19203/; http://dx.doi.org/10.1038/srep42980
• Institution: Universiti Malaya

In this study, we first performed whole exome sequencing of DNA from 10 untreated and clinically annotated fresh frozen nasopharyngeal carcinoma (NPC) biopsies and matched bloods to identify somatically mutated genes that may be amenable to targeted therapeutic strategies. We identified a total of 3...