Nutlin-3 sensitizes nasopharyngeal carcinoma cells to cisplatin-induced cytotoxicity

• Main Authors: Voon, Y.L., Ahmad, M., Wong, P.F., Husaini, R., Ng, W.T.W., Leong, C.O., Lane, D.P., Khoo, A.S.B.
• Format: Article
• Published: Spandidos Publications 2015
• Subjects: R Medicine; RM Therapeutics. Pharmacology; RS Pharmacy and materia medica
• Online Access: http://eprints.um.edu.my/19489/; http://dx.doi.org/10.3892/or.2015.4177
• Institution: Universiti Malaya

The small-molecule inhibitor of p53-Mdm2 interaction, Nutlin-3, is known to be effective against cancers expressing wild-type (wt) p53. p53 mutations are rare in nasopharyngeal carcinoma (NPC), hence targeting disruption of p53-Mdm2 interaction to reactivate p53 may offer a promising therapeutic str...