Hyper-Expression of PD-1 Is Associated with the Levels of Exhausted and Dysfunctional Phenotypes of Circulating CD161++TCR iVα7.2+ Mucosal-Associated Invariant T Cells in Chronic Hepatitis B Virus Infection

• Main Authors: Yong, Yean K., Saeidi, Alireza, Tan, Hong Y., Rosmawati, Mohamed, Enström, Philip F., Al Batran, Rami, Vasuki, V., Chattopadhyay, Indranil, Murugesan, Amudhan, Vignesh, Ramachandran, Kamarulzaman, Adeeba, Rajarajeswaran, Jayakumar, Ansari, Abdul W., Vadivelu, Jamuna, Ussher, James E., Velu, Vijayakumar, Larsson, Marie, Shankar, Esaki Muthu
• Format: Article
• Published: Frontiers Media 2018
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/20260/; https://doi.org/10.3389/fimmu.2018.00472
• Institution: Universiti Malaya

Mucosal-associated invariant T (MAIT) cells, defined as CD161++TCR iVα7.2+ T cells, play an important role in the innate defense against bacterial infections, and their functionality is impaired in chronic viral infections. Here, we investigated the frequency and functional role of MAIT cells in chr...