Contrasting sirtuin and poly(ADP-ribose)polymerase activities of selected 2,4,6-trisubstituted benzimidazoles

• Main Authors: Yeong, Keng Yoon, Tan, Soo Choon, Mai, Chun-Wai, Leong, Chee-Onn, Chung, Felicia Fei-Lei, Lee, Yean Kee, Chee, Chin Fei, Abd Rahman, Noorsaadah
• Format: Article
• Published: Wiley 2017
• Subjects: Q Science (General); QD Chemistry; R Medicine
• Online Access: http://eprints.um.edu.my/20276/; https://doi.org/10.1111/cbdd.13072
• Institution: Universiti Malaya

Both sirtuin and poly(ADP-ribose)polymerase (PARP) family of enzymes utilize NAD+ as co-substrate. Inhibitors of sirtuins and PARPs are important tools in drug discovery as they are reported to be linked to multiple diseases such as cancer. New potent sirtuin inhibitors (2,4,6-trisubstituted benzimi...