Epidemic dynamics, interactions and predictability of enteroviruses associated with hand, foot and mouth disease in Japan

• Main Authors: Takahashi, Saki, Metcalf, C. Jessica E., Arima, Yuzo, Fujimoto, Tsuguto, Shimizu, Hiroyuki, Rogier van Doorn, H., Le Van, Tan, Chan, Yoke Fun, Farrar, Jeremy J., Oishi, Kazunori, Grenfell, Bryan T.
• Format: Article
• Published: The Royal Society 2018
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/20570/; https://doi.org/10.1098/rsif.2018.0507
• Institution: Universiti Malaya

Outbreaks of hand, foot and mouth disease have been documented in Japan since 1963. This disease is primarily caused by the two closely related serotypes of Enterovirus A71 (EV-A71) and Coxsackievirus A16 (CV-A16). Here, we analyse Japanese virologic and syndromic surveillance time-series data from...