Determination of sofosbuvir and velpatasvir in solid pharmaceutical dosage form by hplc-pda and its application to in vitro dissolution studies

• Main Authors: Tahir, Muhammad Saqlain, Ahmed, Mahmood, Qadir, Muhammad Abdul, Adnan, Ahmad, Syed, Quratulain, Low, Kah Hin, Ikram, Rabia
• Format: Article
• Published: Colegio de Farmaceuticos de la Provincia de Buenos Aires 2018
• Subjects: Q Science (General); QD Chemistry
• Online Access: http://eprints.um.edu.my/20579/; http://www.latamjpharm.org/resumenes/37/6/LAJOP_37_6_1_1.pdf
• Institution: Universiti Malaya

In the present study, a newly developed method based on high performance liquid chromatography (HPLC) was optimized for the simultaneous determination of sofosbuvir (SOFOS) and velpatasvir (VELPA) in commercial tablet formulations. Isocratic separation of SOFOS and VELPA was performed at 40 ºC with...