Computational prediction of changes in brain metabolic fluxes during Parkinson’s disease from mRNA expression

• Main Authors: Supandi, Farahaniza, Van Beek, Johannes H.G.M.
• Format: Article
• Published: Public Library of Science 2018
• Subjects: Q Science (General); QH Natural history
• Online Access: http://eprints.um.edu.my/20590/; https://doi.org/10.1371/journal.pone.0203687
• Institution: Universiti Malaya

Background Parkinson’s disease is a widespread neurodegenerative disorder which affects brain metabolism. Although changes in gene expression during disease are often measured, it is difficult to predict metabolic fluxes from gene expression data. Here we explore the hypothesis that changes in gene...