Modification of anti-cancer co-crystal for thymidylate synthase inhibition: Molecular dynamics study
Raltitrexed (tomudex) is an alternative antifolate drug to 5-fluorouracil (5-FU) to inhibit thymidylate synthase (TS) by decreasing dihydrofolate reductase (DHFR) activity. The clinical trial shows the potential of raltitrexed towards TS inhibition can be enhanced by combining the raltiterexed with...
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| Main Authors: | , , , |
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| Format: | Article |
| Published: |
Faculty of Science, Chiang Mai University
2018
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| Subjects: | |
| Online Access: | http://eprints.um.edu.my/20844/ http://it.science.cmu.ac.th/ejournal/journalDetail.php?journal_id=9522 |
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| Institution: | Universiti Malaya |