Ultrasmall superparamagnetic Fe3O4 nanoparticles: honey-based green and facile synthesis and in vitro viability assay

Introduction: In the present research, we report a quick and green synthesis of magnetite nanoparticles (Fe 3 O 4 -NPs) in aqueous solution using ferric and ferrous chloride, with different percentages of natural honey (0.5%, 1.0%, 3.0% and 5.0% w/v) as the precursors, stabilizer, reducing and cappi...

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Main Authors: Rasouli, Elisa, Basirun, Wan Jefrey, Rezayi, Majid, Shameli, Kamyar, Nourmohammadi, Esmail, Khandanlou, Roshanak, Izadiyan, Zahra, Sarkarizi, Hoda Khoshdel
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Published: Dove Medical Press 2018
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Online Access:http://eprints.um.edu.my/20911/
https://doi.org/10.2147/IJN.S158083
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spelling my.um.eprints.209112019-04-15T09:17:17Z http://eprints.um.edu.my/20911/ Ultrasmall superparamagnetic Fe3O4 nanoparticles: honey-based green and facile synthesis and in vitro viability assay Rasouli, Elisa Basirun, Wan Jefrey Rezayi, Majid Shameli, Kamyar Nourmohammadi, Esmail Khandanlou, Roshanak Izadiyan, Zahra Sarkarizi, Hoda Khoshdel Q Science (General) QD Chemistry Introduction: In the present research, we report a quick and green synthesis of magnetite nanoparticles (Fe 3 O 4 -NPs) in aqueous solution using ferric and ferrous chloride, with different percentages of natural honey (0.5%, 1.0%, 3.0% and 5.0% w/v) as the precursors, stabilizer, reducing and capping agent, respectively. The effect of the stabilizer on the magnetic properties and size of Fe 3 O 4 -NPs was also studied. Methods: The nanoparticles were characterized by X-ray diffraction (XRD) analysis, field emission scanning electron microscopy, energy dispersive X-ray fluorescence, transmission electron microscopy (TEM), vibrating sample magnetometry (VSM) and Fourier transform infrared spectroscopy. Results: The XRD analysis indicated the presence of pure Fe 3 O 4 -NPs while the TEM images indicated that the Fe 3 O 4 -NPs are spherical with a diameter range between 3.21 and 2.22 nm. The VSM study demonstrated that the magnetic properties were enhanced with the decrease in the percentage of honey. In vitro viability evaluation of Fe 3 O 4 -NPs performed by using the MTT assay on the WEHI164 cells demonstrated no significant toxicity in higher concentration up to 140.0 ppm, which allows them to be used in some biological applications such as drug delivery. Conclusion: The presented synthesis method can be used for the controlled synthesis of Fe 3 O 4 -NPs, which could be found to be important in applications in biotechnology, biosensor and biomedicine, magnetic resonance imaging and catalysis. Dove Medical Press 2018 Article PeerReviewed Rasouli, Elisa and Basirun, Wan Jefrey and Rezayi, Majid and Shameli, Kamyar and Nourmohammadi, Esmail and Khandanlou, Roshanak and Izadiyan, Zahra and Sarkarizi, Hoda Khoshdel (2018) Ultrasmall superparamagnetic Fe3O4 nanoparticles: honey-based green and facile synthesis and in vitro viability assay. International Journal of Nanomedicine, 13. pp. 6903-6911. ISSN 1176-9114 https://doi.org/10.2147/IJN.S158083 doi:10.2147/IJN.S158083
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic Q Science (General)
QD Chemistry
spellingShingle Q Science (General)
QD Chemistry
Rasouli, Elisa
Basirun, Wan Jefrey
Rezayi, Majid
Shameli, Kamyar
Nourmohammadi, Esmail
Khandanlou, Roshanak
Izadiyan, Zahra
Sarkarizi, Hoda Khoshdel
Ultrasmall superparamagnetic Fe3O4 nanoparticles: honey-based green and facile synthesis and in vitro viability assay
description Introduction: In the present research, we report a quick and green synthesis of magnetite nanoparticles (Fe 3 O 4 -NPs) in aqueous solution using ferric and ferrous chloride, with different percentages of natural honey (0.5%, 1.0%, 3.0% and 5.0% w/v) as the precursors, stabilizer, reducing and capping agent, respectively. The effect of the stabilizer on the magnetic properties and size of Fe 3 O 4 -NPs was also studied. Methods: The nanoparticles were characterized by X-ray diffraction (XRD) analysis, field emission scanning electron microscopy, energy dispersive X-ray fluorescence, transmission electron microscopy (TEM), vibrating sample magnetometry (VSM) and Fourier transform infrared spectroscopy. Results: The XRD analysis indicated the presence of pure Fe 3 O 4 -NPs while the TEM images indicated that the Fe 3 O 4 -NPs are spherical with a diameter range between 3.21 and 2.22 nm. The VSM study demonstrated that the magnetic properties were enhanced with the decrease in the percentage of honey. In vitro viability evaluation of Fe 3 O 4 -NPs performed by using the MTT assay on the WEHI164 cells demonstrated no significant toxicity in higher concentration up to 140.0 ppm, which allows them to be used in some biological applications such as drug delivery. Conclusion: The presented synthesis method can be used for the controlled synthesis of Fe 3 O 4 -NPs, which could be found to be important in applications in biotechnology, biosensor and biomedicine, magnetic resonance imaging and catalysis.
format Article
author Rasouli, Elisa
Basirun, Wan Jefrey
Rezayi, Majid
Shameli, Kamyar
Nourmohammadi, Esmail
Khandanlou, Roshanak
Izadiyan, Zahra
Sarkarizi, Hoda Khoshdel
author_facet Rasouli, Elisa
Basirun, Wan Jefrey
Rezayi, Majid
Shameli, Kamyar
Nourmohammadi, Esmail
Khandanlou, Roshanak
Izadiyan, Zahra
Sarkarizi, Hoda Khoshdel
author_sort Rasouli, Elisa
title Ultrasmall superparamagnetic Fe3O4 nanoparticles: honey-based green and facile synthesis and in vitro viability assay
title_short Ultrasmall superparamagnetic Fe3O4 nanoparticles: honey-based green and facile synthesis and in vitro viability assay
title_full Ultrasmall superparamagnetic Fe3O4 nanoparticles: honey-based green and facile synthesis and in vitro viability assay
title_fullStr Ultrasmall superparamagnetic Fe3O4 nanoparticles: honey-based green and facile synthesis and in vitro viability assay
title_full_unstemmed Ultrasmall superparamagnetic Fe3O4 nanoparticles: honey-based green and facile synthesis and in vitro viability assay
title_sort ultrasmall superparamagnetic fe3o4 nanoparticles: honey-based green and facile synthesis and in vitro viability assay
publisher Dove Medical Press
publishDate 2018
url http://eprints.um.edu.my/20911/
https://doi.org/10.2147/IJN.S158083
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