Study of interaction between cationic surfactant (CTAB) and paracetamol by electrical conductivity, tensiometric and spectroscopic methods
The interaction of a hydrophilic drug, paracetamol with the cationic surfactant cetyltrimethylammonium bromide (CTAB) in an aqueous media has been investigated by using conductometric, tensiometric and spectroscopic methods. The critical micelle concentration (CMC) values have been determined by two...
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my.um.eprints.211842019-05-09T01:18:43Z http://eprints.um.edu.my/21184/ Study of interaction between cationic surfactant (CTAB) and paracetamol by electrical conductivity, tensiometric and spectroscopic methods Nabi, Arshid Tasneem, Shadma Jesudason, Christopher Gunaseelan Lee, Vannajan Sanghiran Zain, Sharifuddin Md Q Science (General) QD Chemistry The interaction of a hydrophilic drug, paracetamol with the cationic surfactant cetyltrimethylammonium bromide (CTAB) in an aqueous media has been investigated by using conductometric, tensiometric and spectroscopic methods. The critical micelle concentration (CMC) values have been determined by two different methods and both the methods yielded identical CMC values. The experimental data of conductance and surface tension have been correlated against temperature and concentration using standard relations. The pseudophase separation model has been adopted for calculation of various thermodynamic parameters such as standard free energy ΔGm 0, enthalpy, ΔHmic 0, and entropy, ΔSmic 0, of micelle formation. The increase in the micellization with rising temperature is attributed towards the prevailing hydrophobic-hydrophobic increased interactions between the surfactant-drug aqueous mixtures. From the surface tension data the interfacial parameters such as the maximum surface excess concentration, Γmax, standard Gibbs free energy of adsorption at the air/solvent interface, ΔGad 0, and the minimum surface area pre molecule, Amin, were evaluated. Moreover, fourier transform infrared analysis (FTIR) was carried out to estimate the possible interactions prevailing in the miceller systems. Elsevier 2018 Article PeerReviewed Nabi, Arshid and Tasneem, Shadma and Jesudason, Christopher Gunaseelan and Lee, Vannajan Sanghiran and Zain, Sharifuddin Md (2018) Study of interaction between cationic surfactant (CTAB) and paracetamol by electrical conductivity, tensiometric and spectroscopic methods. Journal of Molecular Liquids, 256. pp. 100-107. ISSN 0167-7322 https://doi.org/10.1016/j.molliq.2018.01.185 doi:10.1016/j.molliq.2018.01.185 |
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Q Science (General) QD Chemistry Nabi, Arshid Tasneem, Shadma Jesudason, Christopher Gunaseelan Lee, Vannajan Sanghiran Zain, Sharifuddin Md Study of interaction between cationic surfactant (CTAB) and paracetamol by electrical conductivity, tensiometric and spectroscopic methods |
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The interaction of a hydrophilic drug, paracetamol with the cationic surfactant cetyltrimethylammonium bromide (CTAB) in an aqueous media has been investigated by using conductometric, tensiometric and spectroscopic methods. The critical micelle concentration (CMC) values have been determined by two different methods and both the methods yielded identical CMC values. The experimental data of conductance and surface tension have been correlated against temperature and concentration using standard relations. The pseudophase separation model has been adopted for calculation of various thermodynamic parameters such as standard free energy ΔGm 0, enthalpy, ΔHmic 0, and entropy, ΔSmic 0, of micelle formation. The increase in the micellization with rising temperature is attributed towards the prevailing hydrophobic-hydrophobic increased interactions between the surfactant-drug aqueous mixtures. From the surface tension data the interfacial parameters such as the maximum surface excess concentration, Γmax, standard Gibbs free energy of adsorption at the air/solvent interface, ΔGad 0, and the minimum surface area pre molecule, Amin, were evaluated. Moreover, fourier transform infrared analysis (FTIR) was carried out to estimate the possible interactions prevailing in the miceller systems. |
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Article |
author |
Nabi, Arshid Tasneem, Shadma Jesudason, Christopher Gunaseelan Lee, Vannajan Sanghiran Zain, Sharifuddin Md |
author_facet |
Nabi, Arshid Tasneem, Shadma Jesudason, Christopher Gunaseelan Lee, Vannajan Sanghiran Zain, Sharifuddin Md |
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Nabi, Arshid |
title |
Study of interaction between cationic surfactant (CTAB) and paracetamol by electrical conductivity, tensiometric and spectroscopic methods |
title_short |
Study of interaction between cationic surfactant (CTAB) and paracetamol by electrical conductivity, tensiometric and spectroscopic methods |
title_full |
Study of interaction between cationic surfactant (CTAB) and paracetamol by electrical conductivity, tensiometric and spectroscopic methods |
title_fullStr |
Study of interaction between cationic surfactant (CTAB) and paracetamol by electrical conductivity, tensiometric and spectroscopic methods |
title_full_unstemmed |
Study of interaction between cationic surfactant (CTAB) and paracetamol by electrical conductivity, tensiometric and spectroscopic methods |
title_sort |
study of interaction between cationic surfactant (ctab) and paracetamol by electrical conductivity, tensiometric and spectroscopic methods |
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Elsevier |
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2018 |
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http://eprints.um.edu.my/21184/ https://doi.org/10.1016/j.molliq.2018.01.185 |
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