Endothelial replicative senescence delayed by the inhibition of MTORC1 signaling involves MicroRNA-107

• Main Authors: Khor, Eng Soon, Wong, Pooi Fong
• Format: Article
• Published: Elsevier 2018
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/21606/; https://doi.org/10.1016/j.biocel.2018.05.016
• Institution: Universiti Malaya

Accumulation of senescent endothelial cells can contribute to endothelium dysfunction. Suppression of MTOR signaling has been shown to delay senescence but the mechanism that underpins this effect, particularly one that involves miRNAs, remains to be further defined. This study sought to identify mi...