Antiproliferative effects of imatinib mesylate on ZR‑75‑1 and MDA‑MB‑231 cell lines via PDGFR‑β, PDGF‑BB, c‑Kit and SCF expression

• Main Authors: Kadivar, Ali, Noordin, Mohamed Ibrahim, Aditya, Arya, Kamalidehghan, Behnam, Davoudi, Ehsan Taghizadeh, Sedghi, Reihaneh, Javar, Hamid Akbari
• Format: Article
• Published: Spandidos Publications 2018
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/21719/; https://doi.org/10.3892/ijmm.2018.3590
• Institution: Universiti Malaya

Imatinib mesylate is an anti-neoplastic targeted chemotherapeutic agent, which can inhibit tyrosine kinase receptors, including BCR-ABL, platelet-derived growth factor receptors (PDGFRs) and c-Kit. Cellular processes, including differentiation, proliferation and survival are regulated by these recep...