Phenylpropanoids isolated from Piper sarmentosum Roxb. induce apoptosis in breast cancer cells through reactive oxygen species and mitochondrial-dependent pathways

• Main Authors: Hematpoor, Arshia, Paydar, Mohammadjavad, Liew, Sook Yee, Sivasothy, Yasodha, Mohebali, Nooshin, Looi, Chung Yeng, Wong, Won Fen, Sofian-Azirun, Mohd, Awang, Khalijah
• Format: Article
• Published: Elsevier 2018
• Subjects: QD Chemistry; QH Natural history; R Medicine
• Online Access: http://eprints.um.edu.my/21906/; https://doi.org/10.1016/j.cbi.2017.11.014
• Institution: Universiti Malaya

The aim of the present study is to isolate bioactive compounds from the roots of Piper sarmentosum and examine the mechanism of action using human breast cancer cell line (MDA-MB-231). Bioassay guided-fractionation of methanolic extract led to the isolation of asaricin (1) and isoasarone (2). Asaric...