Erythrocyte-binding assays reveal higher binding of Plasmodium knowlesi Duffy binding protein to human Fya+/b+ erythrocytes than to Fya+/b- erythrocytes

• Main Authors: Fong, Mun Yik, Cheong, Fei Wen, Lau, Yee Ling
• Format: Article
• Published: BMC 2018
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/22065/; https://doi.org/10.1186/s13071-018-3118-8
• Institution: Universiti Malaya

BACKGROUND: The merozoite of the zoonotic Plasmodium knowlesi invades human erythrocytes via the binding of its Duffy binding protein (PkDBPαII) to the Duffy antigen on the eythrocytes. The Duffy antigen has two immunologically distinct forms, Fya and Fyb. In this study, the erythrocyte-binding assa...