Synthesis and anticancer activity of novel water soluble benzimidazole carbamates

• Main Authors: Cheong, Jae Eun, Zaffagni, Michela, Chung, Ivy, Xu, Yingjie, Wang, Yiqiang, Jernigan, Finith E., Zetter, Bruce R., Sun, Lijun
• Format: Article
• Published: Elsevier 2018
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/22243/; https://doi.org/10.1016/j.ejmech.2017.11.037
• Institution: Universiti Malaya

Metastases account for more than 90% of all cancer deaths and respond poorly to most therapies. There remains an urgent need for new therapeutic modalities for the treatment of advanced metastatic cancers. The benzimidazole methylcarbamate drugs, commonly used as anti-helmitics, have been suggested...