Exposure to Silver Nanospheres Leads to Altered Respiratory Mechanics and Delayed Immune Response in an in Vivo Murine Model

• Main Authors: Botelho, Danielle, Leo, Bey Fen, Massa, Christopher, Sarkar, Srijata, Tetley, Terry, Chung, Kian F., Chen, Shu, Ryan, Mary P., Porter, Alexandra, Atochina-Vasserman, Elena N., Zhang, Junfeng, Schwander, Stephan, Gow, Andrew J.
• Format: Article
• Published: Frontiers Media 2018
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/22300/; https://doi.org/10.3389/fphar.2018.00213
• Institution: Universiti Malaya

Here we examine the organ level toxicology of both carbon black (CB) and silver nanoparticles (AgNP). We aim to determine metal-specific effects to respiratory function, inflammation and potential interactions with lung lining fluid (LLF). C57Bl6/J male mice were intratracheally instilled with salin...