Laevifins A–G, clerodane diterpenoids from the Bark of Croton oblongus Burm.f.
A phytochemical investigation of the stem barks of the Malaysian Croton oblongus Burm.f. (Syn. Croton laevifolius Blume) (Euphorbiaceae) yielded seven previously undescribed ent-neo-clerodane diterpenoids, laevifins A - G and the known crovatin (3). Structures were established by a combination of sp...
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my.um.eprints.224102019-09-18T03:37:05Z http://eprints.um.edu.my/22410/ Laevifins A–G, clerodane diterpenoids from the Bark of Croton oblongus Burm.f. Aziz, Ahmad Nazif Ismail, Nor Hadiani Halim, Siti Nadiah Abdul Looi, Chung Yeng Anouar, El Hassane Langat, Moses K. Mulholland, Dulcie Awang, Khalijah Q Science (General) QD Chemistry R Medicine A phytochemical investigation of the stem barks of the Malaysian Croton oblongus Burm.f. (Syn. Croton laevifolius Blume) (Euphorbiaceae) yielded seven previously undescribed ent-neo-clerodane diterpenoids, laevifins A - G and the known crovatin (3). Structures were established by a combination of spectroscopic methods including HRESIMS, NMR spectroscopy and X-ray crystallography. The absolute configuration of crovatin and laevifins A-G was established by comparison of experimental ECD and theoretical TDDFT ECD calculated spectra. This is the first report on the occurrence of the sesquiterpenoid cryptomeridiol in a Croton species. In vitro cytotoxicity assays on laevifins A, B and G showed moderate activities against the MCF-7 cancer cell line (IC50 102, 115 and 106 μM, respectively) while β-amyrin and acetyl aleuritolic acid showed good anti-inflammatory activity on the LPS-induced NF-κB translocation inhibition in RAW 264.7 cells assay with IC50 values of 23.5 and 35.4 μg/mL, respectively. Elsevier 2018 Article PeerReviewed Aziz, Ahmad Nazif and Ismail, Nor Hadiani and Halim, Siti Nadiah Abdul and Looi, Chung Yeng and Anouar, El Hassane and Langat, Moses K. and Mulholland, Dulcie and Awang, Khalijah (2018) Laevifins A–G, clerodane diterpenoids from the Bark of Croton oblongus Burm.f. Phytochemistry, 156. pp. 193-200. ISSN 0031-9422 https://doi.org/10.1016/j.phytochem.2018.10.002 doi:10.1016/j.phytochem.2018.10.002 |
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Q Science (General) QD Chemistry R Medicine Aziz, Ahmad Nazif Ismail, Nor Hadiani Halim, Siti Nadiah Abdul Looi, Chung Yeng Anouar, El Hassane Langat, Moses K. Mulholland, Dulcie Awang, Khalijah Laevifins A–G, clerodane diterpenoids from the Bark of Croton oblongus Burm.f. |
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A phytochemical investigation of the stem barks of the Malaysian Croton oblongus Burm.f. (Syn. Croton laevifolius Blume) (Euphorbiaceae) yielded seven previously undescribed ent-neo-clerodane diterpenoids, laevifins A - G and the known crovatin (3). Structures were established by a combination of spectroscopic methods including HRESIMS, NMR spectroscopy and X-ray crystallography. The absolute configuration of crovatin and laevifins A-G was established by comparison of experimental ECD and theoretical TDDFT ECD calculated spectra. This is the first report on the occurrence of the sesquiterpenoid cryptomeridiol in a Croton species. In vitro cytotoxicity assays on laevifins A, B and G showed moderate activities against the MCF-7 cancer cell line (IC50 102, 115 and 106 μM, respectively) while β-amyrin and acetyl aleuritolic acid showed good anti-inflammatory activity on the LPS-induced NF-κB translocation inhibition in RAW 264.7 cells assay with IC50 values of 23.5 and 35.4 μg/mL, respectively. |
format |
Article |
author |
Aziz, Ahmad Nazif Ismail, Nor Hadiani Halim, Siti Nadiah Abdul Looi, Chung Yeng Anouar, El Hassane Langat, Moses K. Mulholland, Dulcie Awang, Khalijah |
author_facet |
Aziz, Ahmad Nazif Ismail, Nor Hadiani Halim, Siti Nadiah Abdul Looi, Chung Yeng Anouar, El Hassane Langat, Moses K. Mulholland, Dulcie Awang, Khalijah |
author_sort |
Aziz, Ahmad Nazif |
title |
Laevifins A–G, clerodane diterpenoids from the Bark of Croton oblongus Burm.f. |
title_short |
Laevifins A–G, clerodane diterpenoids from the Bark of Croton oblongus Burm.f. |
title_full |
Laevifins A–G, clerodane diterpenoids from the Bark of Croton oblongus Burm.f. |
title_fullStr |
Laevifins A–G, clerodane diterpenoids from the Bark of Croton oblongus Burm.f. |
title_full_unstemmed |
Laevifins A–G, clerodane diterpenoids from the Bark of Croton oblongus Burm.f. |
title_sort |
laevifins a–g, clerodane diterpenoids from the bark of croton oblongus burm.f. |
publisher |
Elsevier |
publishDate |
2018 |
url |
http://eprints.um.edu.my/22410/ https://doi.org/10.1016/j.phytochem.2018.10.002 |
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1646210233517735936 |