Macroline–Sarpagine Bisindole Alkaloids with Antiproliferative Activity from Alstonia penangiana

• Main Authors: Yeap, Joanne Soon Yee, Saad, Hazwani Mat, Tan, Chun Hoe, Sim, Kae Shin, Lim, Siew Huah, Low, Yun Yee, Kam, Toh Seok
• Format: Article
• Published: American Chemical Society 2019
• Subjects: Q Science (General); QD Chemistry; QH Natural history
• Online Access: http://eprints.um.edu.my/23107/; https://doi.org/10.1021/acs.jnatprod.9b00712
• Institution: Universiti Malaya

A methanol extract of the stem bark of the Malayan Alstonia penangiana provided seven new bisindole alkaloids, comprising six macroline-sarpagine alkaloids (angustilongines E-K, 1-6) and one macroline-pleiocarpamine bisindole alkaloid (angustilongine L, 7). Analysis of the spectroscopic data (NMR an...