A Cytotoxic Indole Characterized by Incorporation of a Unique Carbon–Nitrogen Skeleton and Two Pentacyclic Corynanthean Alkaloids Incorporating a Substituted Tetrahydrofuranone Ring from Kopsia arborea

• Main Authors: Wong, Soon Kit, Wong, Suet Pick, Sim, Kae Shin, Lim, Siew Huah, Low, Yun Yee, Kam, Toh Seok
• Format: Article
• Published: American Chemical Society 2019
• Subjects: Q Science (General); QD Chemistry; QH Natural history; QR Microbiology
• Online Access: http://eprints.um.edu.my/23156/; https://doi.org/10.1021/acs.jnatprod.9b00255
• Institution: Universiti Malaya

Three new alkaloids were isolated from the bark extract of the Malayan Kopsia arborea, viz., arbophyllidine (1), an unusual pentacyclic, monoterpenoid indole characterized by an absence of oxygen atoms and incorporating a new carbon-nitrogen skeleton, and arbophyllinines A (2) and B (3), two pentacy...