Endogenous Annexin-A1 Negatively Regulates Mast Cell-Mediated Allergic Reactions

• Main Authors: Sinniah, Ajantha, Yazid, Samia, Bena, Stefania, Oliani, Sonia M., Perretti, Mauro, Flower, Rod J.
• Format: Article
• Published: Frontiers Media 2019
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/23417/; https://doi.org/10.3389/fphar.2019.01313
• Institution: Universiti Malaya

Mast cell stabilizers like cromoglycate and nedocromil are mainstream treatments for ocular allergy. Biochemical studies in vitro suggest that these drugs prevent mast cell degranulation through the release of Annexin-A1 (Anx-A1) protein. However, the direct effect of Anx-A1 gene deletion on mast ce...