Amino acid signatures of HLA Class-I and II molecules are strongly associated with SLE susceptibility and autoantibody production in Eastern Asians

• Main Authors: Absher, Devin M, Molineros, Julio E., Looger, Loren L., Kim, Kwangwoo, Okada, Yukinori, Terao, Chikashi, Sun, Celi, Zhou, Xu-jie, Raj, Prithvi, Kochi, Yuta, Suzuki, Akari, Akizuki, Shuji, Nakabo, Shuichiro, Bang, So Young, Lee, Hye Soon, Kang, Young Mo, Suh, Chang Hee, Chung, Won Tae, Park, Yong Beom, Choe, Jung Yoon, Shim, Seung Cheol, Lee, Shin Seok, Zuo, Xiaoxia, Yamamoto, Kazuhiko, Li, Quan Zhen, Shen, Nan, Porter, Lauren L., Harley, John B., Chua, Kek Heng, Zhang, Hong, Wakeland, Edward K., Tsao, Betty P., Bae, Sang Cheol, Nath, Swapan K.
• Format: Article
• Published: Public Library of Science 2019
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/23970/; https://doi.org/10.1371/journal.pgen.1008092
• Institution: Universiti Malaya

Human leukocyte antigen (HLA) is a key genetic factor conferring risk of systemic lupus erythematosus (SLE), but precise independent localization of HLA effects is extremely challenging. As a result, the contribution of specific HLA alleles and amino-acid residues to the overall risk of SLE and to r...