Combined effects of isothiocyanates (ITCs) intake, glutathione S-transferases (GSTs) polymorphism and risk habits on oral squamous cell carcinoma (OSCC) associated with earlier age of disease onset

• Main Authors: Karen-Ng, L.P., Marhazlinda, J., Rahman, Z.A.A., Abraham, M.T., Cheong, S.C., Zain, R.B.
• Format: Article
• Language: English; English
• Published: Elsevier 2011
• Subjects: R Medicine; RK Dentistry; Oral surger
• Online Access: http://eprints.um.edu.my/2416/1/Combined.pdf; http://eprints.um.edu.my/2416/2/Combined_effects_of_isothiocyanates__intake.pdf; http://eprints.um.edu.my/2416/; https://doi.org/10.1016/j.oraloncology.2011.06.156
• Institution: Universiti Malaya

Introduction: ITCs found in cruciferous vegetables has been reported to reduce cancer risk by inducing phase II conjugating enzymes, in particular GSTs. Interestingly, these enzymes also metabolize ITCs therefore; the protective effects of ITCs would depend on the activity of GSTs. This study aimed...