Aldehyde dehydrogenase 2 (ALDH2) and glutathione S-transferase M1 (GSTM1) polymorphisms in relation to oral cancer risk among Malaysians

• Main Authors: Karen-Ng, L.P., Ghani, W.M.N., Vimmitra, A., Yuen, K.M., Tan, H.S., Lim, S.J., Abraham, M.T., Rahman, Z.A.A., Tay, K.K., Mustafa, W.M.W., Jalil, N., Norlida, A., Cheong, S.C., Zain, R.B.
• Format: Article
• Language: English; English
• Published: Elsevier 2011
• Subjects: R Medicine; RK Dentistry; Oral surger
• Online Access: http://eprints.um.edu.my/2422/1/Aldehyde_dehydrogenase_2_%28ALDH2%29_and_glutathione_S-transferase_M1_%28GSTM1%29_polymorphisms_in_relation_to_oral_cancer_risk_among_Malaysians.pdf; http://eprints.um.edu.my/2422/2/aldehyde.pdf; http://eprints.um.edu.my/2422/; https://doi.org/10.1016/j.oraloncology.2011.06.157
• Institution: Universiti Malaya

Introduction: ALDH2 is an enzyme involved in major oxidative pathway of alcohol metabolism while GSTM1 is a drug-metabolizing enzyme of acetaldehyde. It has been reported that the mutant ALDH2 allele and the absence of GSTM1 contributes to increased oral cancer risk due to reduced acetaldehyde metab...