Investigation of Boldine as a Potential Telomerase Inhibitor by Downregulation of hTERT/hTERC in HCT 116 Human Colon Carcinoma Cells

• Main Authors: Ahmad, Nadhirah, Ching, Joo Jie, Majid, Nazia Abdul
• Format: Article
• Published: Penerbit Universiti Kebangsaan Malaysia 2019
• Subjects: Q Science (General); QH Natural history
• Online Access: http://eprints.um.edu.my/24358/; https://doi.org/10.17576/jsm-2019-4809-04
• Institution: Universiti Malaya

Telomerase, a ribonucleoprotein (RNP) complex, is a type of RNA-dependent DNA polymerase that synthesises telomeric DNA repeats (TTAGGG) at the 3' end of chromosomes. Most of the cancer cells express high level of telomerase which results in cellular immortality. The high telomerase activity in...