Geranylated 4-phenylcoumarins extracted from Mesua elegans induced caspase-independent cell death in prostate cancer cell lines through calpain-2 and cathepsin B

Geranylated 4-phenylcoumarins extracted from Mesua elegans induced caspase-independent cell death in prostate cancer cell lines through calpain-2 and cathepsin B

Geranylated 4-phenylcoumarins DMDP-1 and DMDP-2 isolated from Mesua elegans were elucidated for their role in inducing caspase-independent programmed cell death (CI-PCD) in prostate cancer cell lines, PC-3 and DU 145, respectively. Cell homeostasis disruption was demonstrated upon treatment, as show...

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Bibliographic Details
Main Authors: Sapili, Hani, Ho, Chai San, Malagobadan, Sharan, Arshad, Norhafiza Mohd, Nagoor, Noor Hasima
Format: Article
Published: Nature Research 2020
Subjects:
Q Science (General)
QH Natural history
Online Access:http://eprints.um.edu.my/25129/
https://doi.org/10.1038/s41598-020-57781-6
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Institution: Universiti Malaya

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http://eprints.um.edu.my/25129/
https://doi.org/10.1038/s41598-020-57781-6

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